Digital technologies offer new opportunities for learning in an increasingly connected society, in which learning to work with others and collaborate has become an extremely important skill. This article presents the results of a research study into the conceptions and practices of working teachers regarding collaborative learning methodologies mediated by information and communication technologies (ICT) in Elementary and Secondary Education schools. We analyze data concerning ICT contributions to collaborative work processes in the classroom, from the point of view of teachers at schools accredited with a high level of ICT by the Regional Government of Castile and Leon. We furthermore take into account the limitations of these tools, as well as teachers’ conceptions of collaborative learning strategies. The methodology is based on the content analysis of interviews of teachers from a representative sample of schools. The results indicate that teachers think that ICT have great potential for enhancing collaborative activities among students and for developing highly relevant generic skills, although they are also aware of the difficulties that both students and teachers face in educational practice.